Nephrotoxicity and fungal resistance associated with Amphotericin B

Introduction: Amphotericin B (AB) is the drug of choice for treatment several systemic fungal infections. Despite its effectiveness and minimum relation to resistance, AB toxic animal cells, in particular kidney cells. Objective: To address aspects nephrotoxicity biomarkers available early detection disease caused by AB. Method: The bibliographic search was performed online databases. Papers published between 2008-2019, were selected further analysis inclusion present review. Results: resulted 42 eligible papers which main findings were: (i) frequency resistance appears be substantial, however, some species should carefully studied given their diminished susceptibility; (ii) regarding nephrotoxicity, new techniques methods have promisingly been implemented; (iii) a novel generation injury more specific sensitive. Conclusion: adoption conjugated delivery systems consistent alternative minimize resistance. Considering biomarkers, it likely that, instead punctual assessment single biomarker, set provides thorough comprehension related AB-induced injury. Nonetheless, clinical studies are necessary implementation such routine. Keywords: B. Nephrotoxicity. Acute Kidney Injury. Biomarkers.